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all of the engines currently still use an interpreter for QVM (which means really bad performance, noticeable in the mod CPMA), quake3e plans on having native support for ppc64le eventually.
I'm pretty sure he's referencing to your own feature request.
Quake3e still needs a bytecode compiler for ppc64le if you were still interested in helping with that.
I don't think this would work as written for the original PowerPC Q3VM, which was big-endian (little-endian PowerPC wasn't really a thing in those days). There may also be a few 32-64 bit edges, though I would think that would be minor.