No, I wasn't really being sarcastic (maybe a little snarky).
My concern here is the amount of cooling that would make it liveable as a workstation. The board is clearly able to handle it and I don't have any reliability concerns given how overengineered the II board is, but the HSFs will probably be whining all the time unless you have it parked somewhere else as a host where you don't have to listen to it. I would also imagine the TDP would cause a lot of heat in a typical room. I've always thought the 22s were better in server configurations.